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External links Category:1996 video games Category:Racing video games Category:Video games developed in the United Kingdom Category:Windows games Category:Windows-only gamesSynthesis of a series of small-molecule inhibitors of Grb7 SH2 domain-mediated signalling. A set of small-molecule inhibitors of Grb7 SH2 domain-mediated signalling has been synthesised. The compounds are based on an imidazopyridine scaffold which binds in a similar way to the surface of the protein and provides a binding site for a variety of scaffold derivatisation. Three compounds have been characterised in a biological assay, with binding affinities between 1 and 2 microM. Binding was shown to be pH dependent with a pK(a) of approximately 6, a common feature of all SH2 domains.Q: How do I create a shiny app with an actionButton? I am trying to create a shiny app which accepts search parameters and then performs an action. The code I have so far is: library(shiny) ui



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